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KMID : 0613820070170101354
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Journal of Life Science
2007 Volume.17 No. 10 p.1354 ~ p.1360
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Effect of Tea Polyphenols on Anticancer Activity and Cytokines Production
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Shon Mi-Yae
Nam Sang-Hae
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Abstract
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Theaflavins (TF) and thearubigins (TR) are constituents of tea pigments which are polyphenols derived from Korean fermentation tea. After TF, TR and [(-) epigallocatechin-3-gallate ](EGCG) have been applied to macrophage cell line (RAW264.7) nitric oxide (NO) synthesis and cytokines production were estimated. Cytokines production by enzyme linked immuno-sorbent assay (ELISA) determined. NO production was increased by about 1.5-folds at the dose of 80 μg/ml compared to control and lipopolysaccharide (LPS) stimulation when TF, TR and EGCG were applied to a RAW264.7 cell. Interleukin-6 (IL-6), Tumor necrosis factor (TNF-α) and granulocyte-macrophage colony stimulating factor (GM-CSF) increased depended on concentrations of TF, TR and EGCG. The production of tumor necrosis factor-α increased highly in TR, TF and EGCG group with LPS. These results suggest that TF, TR and EGCG have immune-enhancement effect through the cytokine production. TF, TR and EGCG inhibited cancer cell viability, the anticancer effect of these polyphenols may explain the anti-tumor promotion action and antioxidant activity of these tea constituents.
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KEYWORD
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Theaflavins (TF), thearubigins (TR), immunomodulator cytokine, anticancer activity, antioxidant activity
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